Anti-MIP-3 alpha CCL20 Antibody

About this product

Boster Bio Anti-MIP-3 alpha CCL20 Antibody catalog # A00748. Tested in IHC, IF, ELISA applications. This antibody reacts with Human, Mouse.

Specifications

Catalog number

A00748

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Macrophage Inflammatory Protein 3alpha (MIP3alpha), also called Chemokine, cc motif, ligand 20 (CCL20) . The MIP-3alpha/CCL20 gene was cloned and sequenced, revealing a four exon, three intron structure, and was localized by FISH analysis to 2q35-q36. MIP3alpha is predominantly expressed in lymph nodes, appendix, PBL, fetal liver, fetal lung and several cell lines. MIP3alpha/CCL20 and its receptor CCR6 are markedly up-regulated in psoriasis, and they may play a role in the recruitment of T cells to lesional psoriatic skin. And Alanine MIP-3alpha and Serine MIP-3alpha, the two forms of MIP3alpha, that differ by one amino acid at the predicted signal peptide cleavage site. Both of them were chemically synthesized and tested for biological activity. And both flu antigen plus IL-2-activated CD4 (+) and CD8 (+) T lymphoblasts and cord blood-derived dendritic cells responded to Ser and Ala MIP-3alpha.

Synonyms

C-C motif chemokine 20; Beta-chemokine exodus-1; CC chemokine LARC; Liver and activation-regulated chemokine; Macrophage inflammatory protein 3 alpha; MIP-3-alpha; Small-inducible cytokine A20; CCL20 (1-67) ; CCL20 (1-64) ; CCL20 (2-70) ; CCL20; LARC, MIP3A, SCYA20

Gene Name

CCL20

UniProt

P78556

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Synthetic peptide from human protein at AA range: 31-80

Clonality

Polyclonal

Tissue Specificity

Expressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, and fetal lung. Low levels seen in thymus, prostate, testis, small intestine and colon.

Applications

IHC, IF, ELISA

Purification

Immunogen affinity purified

Concentration

1 mg/mL

Form

Liquid

Function

Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial activity E.coli ATCC 25922 and S.aureus ATCC 29213. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

10762 MW

Gene Name Synonym

C-C motif chemokine 20

Subcellular Location

Secreted.

Prediction Reactivity

Pig, Bovine

Isotype

IgG

Contents

PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.