Anti-Transcription factor SOX-10 SOX10 Antibody

About this product

Boster Bio Anti-Transcription factor SOX-10 SOX10 Antibody (Catalog # A00758) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A00758

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

SOX10 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and the determination of the cell fate (1) . The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins (2) . This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development (2) . Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschprung disease (3) . SLC30A8 expression in beta-cells was found to be influenced by cytokine expression, particularly IFN-gamma and IL-1beta (4) .

Synonyms

SRY (sex determining region Y) -box 10, DOM, WS4, PCWH, WS2E, WS4C

Gene Name

SOX10

UniProt

P56693

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

SOX10 Antibody is predicted to not cross-react with other SOX familiy members.

Immunogen

SOX10 antibody was raised against a peptide corresponding to 18 amino acids near the amino terminus of human SOX10.

Clonality

Polyclonal

Tissue Specificity

Expressed in fetal brain and in adult brain, heart, small intestine and colon.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Signal Transduction, Stem Cells

Purification

SOX10 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3 (PubMed:21965087) .

Storage Conditions

SOX10 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

49911 MW

Gene Name Synonym

SRY-box 10

Subcellular Location

Cytoplasm

Prediction Reactivity

Pig, Chicken, Goat

Protein Name

SRY-box 10

Isotype

IgG

Contents

SOX10 Antibody is supplied in PBS containing 0.02% sodium azide.