Anti-TGF Beta RII (I122) TGFBR2 Antibody

Catalog number A00759

Price for A00759

Size / count 100 µL

About this product

Boster Bio Anti-TGF Beta RII (I122) TGFBR2 Antibody catalog # A00759. Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number: A00759
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
Synonyms: TGF-beta receptor type-2; TGFR-2;2.7.11.30; TGF-beta type II receptor; Transforming growth factor-beta receptor type II; TGF-beta receptor type II; TbetaR-II; TGFBR2
Gene Name: TGFBR2
UniProt: P37173
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 100-150 of Human TGFβ RII.
Clonality: Polyclonal
Applications: WB, IHC
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration: 1 mg/mL
Form: Liquid
Function: Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non- canonical, SMAD-independent TGF-beta signaling pathways.
Storage Conditions: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight: 64568 MW
Gene Name Synonym: TGF-beta receptor type-2
Subcellular Location: Cell membrane
Protein Name: TGF-beta receptor type-2
Contents: Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Frequently Asked Questions

What is the catalog number for Anti-TGF Beta RII (I122) TGFBR2 Antibody?

The catalog number for Anti-TGF Beta RII (I122) TGFBR2 Antibody is A00759.

What sizes are available for Anti-TGF Beta RII (I122) TGFBR2 Antibody?

Anti-TGF Beta RII (I122) TGFBR2 Antibody is available in the following size(s): 100 µL.

Is Anti-TGF Beta RII (I122) TGFBR2 Antibody in stock?

Anti-TGF Beta RII (I122) TGFBR2 Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Where can I find the safety data sheet (SDS/MSDS) for Anti-TGF Beta RII (I122) TGFBR2 Antibody?

The safety data sheet for Anti-TGF Beta RII (I122) TGFBR2 Antibody is available here: https://www.bosterbio.com/msds?sku=A00759.

What is Anti-TGF Beta RII (I122) TGFBR2 Antibody used for?

Boster Bio Anti-TGF Beta RII (I122) TGFBR2 Antibody catalog # A00759. Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.

Can you help me confirm if this product is right for my specific experiment?

Yes, contact us with details of your sample type, species, and intended application, and our specialists will confirm suitability or suggest an alternative from our supplier network if this isn’t the best fit.

What is the purity of this recombinant protein?

Purity, typically assessed by SDS-PAGE, is listed on the datasheet under quality control data.

What do I do if this product arrives with reduced ice or a damaged cold-chain package?

Report this to us immediately with photos and your order reference. Our specialists will assess whether the product is still usable given the cold-chain interruption, and will arrange a replacement or credit if it isn’t.