Anti-Activin Receptor Type IA (ACVR1) Antibody (N-term)

About this product

Boster Bio Anti-Activin Receptor Type IA (ACVR1) Antibody (N-term) (Catalog # A00798-3) . Tested in WB, IHC-P application (s) . This antibody reacts with Human, Rat.

Specifications

Catalog number

A00798-3-400ul

Size / count

400 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1 is an activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors.

Synonyms

Activin receptor type-1, Activin receptor type I, ACTR-I, Activin receptor-like kinase 2, ALK-2, Serine/threonine-protein kinase receptor R1, SKR1, TGF-B superfamily receptor type I, TSR-I, ACVR1, ACVRLK2

Gene Name

ACVR1

UniProt

Q04771

Host

Rabbit

Reactivity

Human, Rat

Immunogen

This Activin Receptor Type IA (ACVR1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-34 amino acids from the N-terminal region of human Activin Receptor Type IA (ACVR1) .

Clonality

Polyclonal

Tissue Specificity

Expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells

Applications

WB, IHC-P

Field of Research

Signal Transduction

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Function

20628059229772371791140125354296974822817911401

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

57153 Da

Subcellular Location

Membrane; Single-pass type I membrane protein.

Prediction Reactivity

Bovine

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.