Anti-Csk (phospho-S364) Antibody

About this product

Boster Bio Anti-Csk (phospho-S364) Antibody catalog # A00799S364. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A00799S364

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Tyrosine-protein kinase CSK;2.7.10.2

Gene Name

CSK

UniProt

P41240

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic phosphopeptide derived from human Csk around the phosphorylation site of Serine 364.

Clonality

Polyclonal

Tissue Specificity

Expressed in lung and macrophages.

Applications

WB

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T- cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

50704 MW

Applications Notes

WB: 1:500-1:1000

Gene Name Synonym

Tyrosine-protein kinase CSK

Subcellular Location

Cytoplasm . Cell membrane . Mainly cytoplasmic, also present in lipid rafts. .

Protein Name

Tyrosine-protein kinase CSK

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2