Anti-MuSK Monoclonal Antibody

About this product

Boster Bio Anti-MuSK Monoclonal Antibody catalog # A00815. Tested in IHC, IF, ELISA applications. This antibody reacts with Human.

Specifications

Catalog number

A00815

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Muscle, skeletal receptor tyrosine-protein kinase;2.7.10.1 ; Muscle-specific tyrosine-protein kinase receptor; MuSK; Muscle-specific kinase receptor; MUSK

Gene Name

MUSK

UniProt

O15146

Host

Mouse

Reactivity

Human

Immunogen

Purified recombinant extracellular fragment of human MuSK (aa24-209) fused with hIgGFc tag expressed in HEK293 cell line.

Clonality

Monoclonal

Clone

Clone: 10A4

Applications

IHC, IF, ELISA

Purification

Affinity purification

Concentration

1 mg/mL

Form

Liquid

Function

Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle (PubMed:25537362) . Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation (By similarity) . .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

97056 MW

Gene Name Synonym

Muscle, skeletal receptor tyrosine-protein kinase

Subcellular Location

Cell junction, synapse, postsynaptic cell membrane ; Single-pass type I membrane protein . Colocalizes with acetylcholine receptors (AChR) to the postsynaptic cell membrane of the neuromuscular junction. .

Isotype

IgG1

Contents

Ascitic fluid containing 0.03% sodium azide.