Anti-FGA Antibody (N-term)

About this product

Boster Bio Anti-FGA Antibody (N-term) (Catalog # A00816) . Tested in WB, IF, IHC-P application (s) . This antibody reacts with Human.

Specifications

Catalog number

A00816-400ul

Size / count

400 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

FGA is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types.

Synonyms

Fibrinogen alpha chain, Fibrinopeptide A, Fibrinogen alpha chain, FGA

Gene Name

FGA

UniProt

P02671

Host

Rabbit

Reactivity

Human

Immunogen

This FGA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 116-144 amino acids from the N-terminal region of human FGA.

Clonality

Polyclonal

Tissue Specificity

Detected in blood plasma (at protein level) .

Applications

WB, IF, IHC-P

Field of Research

Cardiovascular, Metabolism, Immunology, Innate Immunity

Purification

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Function

Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

94973 Da

Subcellular Location

Secreted

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.