Anti-Dyrk1A (Q39) Antibody

About this product

Boster Bio Anti-Dyrk1A (Q39) Antibody catalog # A00878. Tested in WB, IHC, IF applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A00878

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Dual specificity tyrosine-phosphorylation-regulated kinase 1A;2.7.12.1

Gene Name

DYRK1A

UniProt

Q13627

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide, corresponding to amino acids 6-58 of Human Dyrk1A.

Clonality

Polyclonal

Tissue Specificity

Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney.

Applications

WB, IHC, IF

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity) . Exhibits a substrate preference for proline at position P+1 and arginine at position P- 3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (By similarity) .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

85584 MW

Gene Name Synonym

Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Subcellular Location

Nucleus

Protein Name

Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2