Anti-Pannexin-1 PANX1 Antibody

About this product

Boster Bio Anti-Pannexin-1 PANX1 Antibody (Catalog # A00915) . Tested in ELISA, WB, IF applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A00915

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

The pannexin gene family encodes a second class of putative gap junction proteins and are highly conserved in invertebrates and mammals. Pannexins (Panx) are four-pass transmembrane proteins that oligomerize to form large pore ion and metabolite-permeable channels. Pannexin-1 (PANX1) and Pannexin-3 are closely related, while Pannexin-2 is a more distant relation. PANX1 is a transmembrane protein that forms a mechanosensitive ATP-permeable channel between adjacent cells and in the endoplasmic reticulum. PANX1 may play a role as a Ca2+ -leak channel to regulate ER Ca2+ homeostasis and regulates neural stem and progenitor cell proliferation.

Synonyms

PX1, MRS1, UNQ2529, UNQ2529/PRO6028, Pannexin-1

Gene Name

PANX1

UniProt

Q96RD7

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

Two transcript variants encoding different isoforms have been found for this gene.

Immunogen

Rabbit polyclonal PANX1 antibody was raised against a 17 amino acid peptide near the amino terminus of human PANX1. The immunogen is located within amino acids 70 - 120 of PANX1.

Clonality

Polyclonal

Applications

ELISA, WB, IF

Field of Research

Stem Cells, Inflammasomes

Purification

PANX1 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Structural component of the gap junctions and the hemichannels. May play a role as a Ca (2+) -leak channel to regulate ER Ca (2+) homeostasis.

Storage Conditions

PANX1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

48050 MW

Gene Name Synonym

Pannexin 1

Subcellular Location

Cell membrane ; Multi-pass membrane protein

Protein Name

Pannexin 1

Isotype

IgG

Contents

PANX1 Antibody is supplied in PBS containing 0.02% sodium azide.