Anti-ADP-ribosylation factor 6 ARF6 Antibody

About this product

Boster Bio Anti-ADP-ribosylation factor 6 ARF6 Antibody (Catalog # A00927) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A00927

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

The ADP-ribosylation factor 6 (ARF6) is a member of the ARF family, which is part of the RAS superfamily (1) . The ARF proteins are small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D (2) . The product of this gene is localized to the plasma membrane (3), and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling (4) .

Synonyms

ADP-ribosylation factor 6

Gene Name

ARF6

UniProt

P62330

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

ARF6 antibody is human, mouse and rat reactive.

Immunogen

ARF6 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human ARF6. The immunogen is located within the last 50 amino acids of ARF6.

Clonality

Polyclonal

Tissue Specificity

Ubiquitous, with higher levels in heart, substantia nigra, and kidney.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Signal Transduction

Purification

ARF6 antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling (PubMed:11266366, PubMed:21170023, PubMed:16737952, PubMed:7589240, PubMed:18400762) . Required for normal completion of mitotic cytokinesis (By similarity) . Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers (By similarity) . Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension (PubMed:14978216) . Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization. Regulates surface levels of adherens junction proteins such as CDH1 (By similarity) . Required for NTRK1 sorting to the recycling pathway from early endosomes (By similarity) .

Storage Conditions

ARF6 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Observed Molecular Weight

20082 MW

Gene Name Synonym

ADP-ribosylation factor 6

Subcellular Location

Cytoplasm, cytosol

Prediction Reactivity

Pig, Chicken

Protein Name

ADP-ribosylation factor 6

Isotype

IgG

Contents

ARF6 antibody is supplied in PBS containing 0.02% sodium azide.