- Catalog number
- A00962
- Size / count
- 100 µL
- Dry ice
- No
- Hazardous
- No
- Discontinued
- No
- Synonyms
- Forkhead box protein C1; Forkhead-related protein FKHL7; Forkhead-related transcription factor 3; FREAC-3; FOXC1; FKHL7, FREAC3
- Gene Name
- FOXC1
- UniProt
- Q12948/Q99958
- Host
- Rabbit
- Reactivity
- Human, Mouse, Rat
- Immunogen
- Synthetic peptide, corresponding to amino acids 100-150 of Human FoxC1.
- Clonality
- Polyclonal
- Tissue Specificity
- Expressed in keratinocytes of epidermis and hair follicle (PubMed:27907090) . Expressed strongly in microvascular invasion (MVI) formation, basal-like breast cancer (BLBC) and hepatocellular tumors (PubMed:20406990, PubMed:22991501) . Expressed in breast cancers (at protein level) (PubMed:26565916) . Expressed in hematopoietic cells (PubMed:8499623) .
- Applications
- WB, IHC, IF
- Purification
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
- Concentration
- 1 mg/mL
- Form
- Liquid
- Function
- DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development (PubMed:11782474, PubMed:15299087, PubMed:15684392, PubMed:16492674, PubMed:27907090, PubMed:14506133, PubMed:14578375, PubMed:15277473, PubMed:16449236, PubMed:17210863, PubMed:19793056, PubMed:19279310, PubMed:25786029, PubMed:27804176) . Acts either as a transcriptional activator or repressor (PubMed:11782474) . Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes (PubMed:7957066, PubMed:11782474, PubMed:12533514, PubMed:14506133, PubMed:19793056, PubMed:27804176) . Upon DNA-binding, promotes DNA bending (PubMed:7957066, PubMed:14506133) . Acts as a transcriptional coactivator (PubMed:26565916) . Stimulates Indian hedgehog (Ihh) - induced target gene expression mediated by the transcription factor GLI2, and hence regulates endochondral ossification (By similarity) . Acts also as a transcriptional coregulator by increasing DNA-binding capacity of GLI2 in breast cancer cells (PubMed:26565916) . Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye (PubMed:17993506) . Cooperates with transcription factor FOXC2 in regulating expression of genes that maintain podocyte integrity (By similarity) . Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals (PubMed:12408963) . Involved in epithelial- mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion (PubMed:20406990, PubMed:22991501) . Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity) . Plays a role in the gene regulatory network essential for epidermal keratinocyte terminal differentiation (PubMed:27907090) . Essential developmental transcriptional factor required for mesoderm-derived tissues, such as the somites, skin, bone and cartilage. Positively regulates CXCL12 and stem cell factor expression in bone marrow mesenchymal progenitor cells, and hence plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC) . Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner. Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (By similarity) . May function as a tumor suppressor (PubMed:12408963) .
- Storage Conditions
- Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
- Observed Molecular Weight
- 56789 MW
- Gene Name Synonym
- Forkhead box protein C1
- Subcellular Location
- Nucleus
- Protein Name
- Forkhead box protein C1
- Contents
- Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
