Anti-Phospho-LATS1/2 (T1079/1041) Antibody

About this product

Boster Bio Anti-Phospho-LATS1/2 (T1079/1041) Antibody catalog # A01051T1079. Tested in IHC, IF, ELISA applications. This antibody reacts with Human, Mouse.

Specifications

Catalog number

A01051T1079

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Serine/threonine-protein kinase LATS1;2.7.11.1; Large tumor suppressor homolog 1; WARTS protein kinase; h-warts; LATS1

Gene Name

LATS1

UniProt

O95835

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

The antiserum was produced against synthesized peptide derived from human LATS1/2 around the phosphorylation site of Thr1079/1041. AA range:1041-1090

Clonality

Polyclonal

Tissue Specificity

Expressed in all adult tissues examined except for lung and kidney.

Applications

IHC, IF, ELISA

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/mL

Form

Liquid

Function

Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function. Plays a role in mammary gland epithelial cells differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668) .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

126870 MW

Gene Name Synonym

Serine/threonine-protein kinase LATS1

Subcellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome

Protein Name

Serine/threonine-protein kinase LATS1

Isotype

IgG

Contents

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.