Anti-SCARB1 Antibody

About this product

Boster Bio Anti-SCARB1 Antibody (Catalog # A01093) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A01093

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Scavenger receptor class B member 1 (SCARB1), also known as SR-BI, is part of the scavenger receptor superfamily, which is composed of many members with diverse structures, expression patterns, and functions. SCARB1 is a multi-ligand cell-surface receptor that mediates the selective uptake of lipid from HDL cholesterol into cells and is expressed in steroidogenic tissues in adult animals. Other ligands of SCARB1 include native, acetylated, or oxidized LDL and anionic phospholipids. SCARB1-deficient mice have elevated HDL levels and increased susceptibility to atherosclerosis on fat feeding, indicating its importance in the regulation of cholesterol homeostasis. Along with CLDN1, LDL-R, and the tetraspanin superfamily member CD81, SCARB1 has been reported to be an entry factor for the Hepatitis C virus.

Synonyms

CLA1, SRB1, CLA-1, SR-BI, CD36L1, HDLQTL6, CLA1, Scavenger receptor class B member 1, CD36 and LIMPII analogous 1

Gene Name

SCARB1

UniProt

Q8WTV0

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

At least two isoforms of SCARB1 are known to exist; this antibody can detect both isoforms.

Immunogen

SCARB1 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human SCARB1. The immunogen is located within amino acids 70 - 120 of SCARB1.

Clonality

Polyclonal

Tissue Specificity

Widely expressed.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Infectious Diseases

Purification

SCARB1 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells (PubMed:12016218, PubMed:12519372, PubMed:21226579) . Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux (PubMed:26965621) . Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity (PubMed:12016218) .

Storage Conditions

SCARB1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

60878 MW

Gene Name Synonym

Scavenger receptor class B, member 1

Subcellular Location

Cell membrane

Prediction Reactivity

Pig, Bovine

Protein Name

Scavenger receptor class B, member 1

Isotype

IgG

Contents

SCARB1 Antibody is supplied in PBS containing 0.02% sodium azide.