Anti-IL-23 Antibody

About this product

Boster Bio Anti-IL-23 Antibody (Catalog # A01097) . Tested in ELISA, WB, IHC-P, ICC, IF applications. This antibody reacts with Human.

Specifications

Catalog number

A01097

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Like interleukin-27 (IL-27), IL-23 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the IL-12p40 subunit and a novel p19 subunit. IL-23 is secreted by activated dendritic cells, macrophages, and monocytes. Its biological activities include enhancing the proliferation of memory T cells and the production of IFN-gamma, IL-12, and TNF-α from activated T cells, and can stimulate macrophages to produce TNF-α and nitric oxide. It has also been shown to possess potent anti-tumor and anti-metastatic activity in mouse models of cancer, suggesting a potential role for IL-23 in therapeutic treatment of cancer.

Synonyms

P19, SGRF, IL-23, IL-23A, IL23P19, UNQ2498/PRO5798, Interleukin-23 subunit alpha, Interleukin-23 subunit p19, IL-23 subunit alpha

Gene Name

IL23A

UniProt

Q9NPF7

Host

Rabbit

Reactivity

Human

Immunogen

Anti-IL-23 antibody was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of mature human IL-23. The immunogen is located the last 50 amino acids of IL-23.

Clonality

Polyclonal

Tissue Specificity

Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level) .

Applications

ELISA, WB, IHC-P, ICC, IF

Field of Research

Immunology, Chemokines, Cytokines

Purification

IL-23 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak- Stat signaling cascade, stimulates memory rather than naive T- cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

Storage Conditions

IL-23 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

20730 MW

Gene Name Synonym

Interleukin 23, alpha subunit p19

Subcellular Location

Secreted

Prediction Reactivity

Guinea Pig, Horse, Mouse, Rat

Protein Name

Interleukin 23, alpha subunit p19

Isotype

IgG

Contents

IL-23 Antibody is supplied in PBS containing 0.02% sodium azide.