Anti-EDA1 Antibody

About this product

Boster Bio Anti-EDA1 Antibody (Catalog # A01113) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A01113

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Ectodysplasin A (EDA1) is a member of the TNF-related ligand family involved in the early epithelial-mesenchymal interaction that regulates ectodermal appendage formation (1) . It is a trimeric type II membrane protein that co-localizes with cytoskeletal structures at the lateral and apical surfaces of cells and can be expressed as eight alternatively spliced isoforms in hair follicles and in the epidermis of adult skin (2,3) . EDAs are required during development, and loss or mutation of EDA1 results in a group of developmental disorders identified as ectodermal dysplasia type 1 (4,5) .

Synonyms

Ectodysplasin A, Ectodermal dysplasia protein, ED1, ED1-A1, ED1-A2, EDA1, EDA2, EDA protein, HED, ODT1, STHAGX1, XHED, XLHED

Gene Name

EDA

UniProt

Q92838

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

EDA1 antibody is human, mouse and rat reactive. Multiple isoforms of EDA1 are known to exist.

Immunogen

EDA1 antibody was raised against an 19 amino acid peptide near the center of human EDA1. The immunogen is located within amino acids 130 - 180 of EDA1.

Clonality

Polyclonal

Tissue Specificity

Not abundant; expressed in specific cell types of ectodermal (but not mesodermal) origin of keratinocytes, hair follicles, sweat glands. Also in adult heart, liver, muscle, pancreas, prostate, fetal liver, uterus, small intestine and umbilical chord.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Stem Cells

Purification

EDA1 antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R (PubMed:8696334, PubMed:11039935, PubMed:27144394) . May also play a role in cell adhesion (By similarity) .

Storage Conditions

EDA1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Observed Molecular Weight

41294 MW

Gene Name Synonym

Ectodysplasin A

Subcellular Location

Cell membrane

Prediction Reactivity

Bovine

Protein Name

Ectodysplasin A

Isotype

IgG

Contents

EDA1 antibody is supplied in PBS containing 0.02% sodium azide.