Anti-ANGPTL4 Antibody (Center)

About this product

Boster Bio Anti-ANGPTL4 Antibody (Center) (Catalog # A01147-1) . Tested in IHC-P, WB, Flow Cytometry application (s) . This antibody reacts with Human.

Specifications

Catalog number

A01147-1-400ul

Size / count

400 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

ANGPTL4 is a member of the angiopoietin/angiopoietin-like gene family and encodes a glycosylated, secreted protein with a fibrinogen C-terminal domain. This protein is induced under hypoxic conditions in endothelial cells and is the target of peroxisome proliferation activators. The encoded protein is a serum hormone directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity and also acts as an apoptosis survival factor for vascular endothelial cells. The encoded protein may play a role in several cancers and it also has been shown to prevent the metastatic process by inhibiting vascular activity as well as tumor cell motility and invasiveness. Decreased expression of this protein has been associated with type 2 diabetes.

Synonyms

Angiopoietin-related protein 4, Angiopoietin-like protein 4, Hepatic fibrinogen/angiopoietin-related protein, HFARP, ANGPTL4, ARP4, HFARP, PGAR

Gene Name

ANGPTL4

UniProt

Q9BY76

Host

Rabbit

Reactivity

Human

Immunogen

This ANGPTL4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 138-167 amino acids from the Central region of human ANGPTL4.

Clonality

Polyclonal

Tissue Specificity

Detected in blood plasma (at protein level) (PubMed:29899519) . Detected in liver (PubMed:10698685) . Detected in white fat tissue and placenta (PubMed:10866690) . Expressed at high levels in the placenta, heart, liver, muscle, pancreas and lung but expressed poorly in the brain and kidney.

Applications

IHC-P, WB, Flow Cytometry

Field of Research

Cancer, Cardiovascular, Metabolism, Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

19270337213986972792937029899144145834581706829517068295

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

45214 Da

Subcellular Location

Secreted. Secreted, extracellular space, extracellular matrix. Note=The unprocessed form interacts with the extracellular matrix (PubMed:17068295, PubMed:21398697) . This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4 (Probable) .

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.