Anti-ZEB2 Antibody

About this product

Boster Bio Anti-ZEB2 Antibody (Catalog # A01169) . Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A01169

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

ZEB2, initially identified as Smad interacting-protein 1, is normally located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Like the homologous ZEB1, ZEB2 inhibits the transcription of the E-cadherin gene and induces epithelial-mesenchymal transition, a genetic program controlling cell migration during embryonic development and wound healing, in vitro. ZEB2 can also protect cells from DNA damage-induced apoptosis, suggesting that its expression may contribute to tumor progression. Recent evidence has shown that ZEB2 is often observed in the cytoplasm in numerous cancer tissues, indicating that its localization may be regulated in normal and tumor tissues. Mutations in this gene are also associated with Hirschsprung disease/Mowat-Wilson syndrome.

Synonyms

SIP1, SIP-1, ZFHX1B, HSPC082, SMADIP1, KIAA0569, SIP1, ZFX1B, HRIHFB2411, Zinc finger E-box-binding homeobox 2, Smad-interacting protein 1

Gene Name

ZEB2

UniProt

O60315

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

ZEB2 antibody is predicted to not cross-react with ZEB1.

Immunogen

ZEB2 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human ZEB2. The immunogen is located within the last 50 amino acids of ZEB2.

Clonality

Polyclonal

Applications

ELISA, WB, ICC, IF

Field of Research

Cancer, Cell Cycle

Purification

ZEB2 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Transcriptional inhibitor that binds to DNA sequence 5'- CACCT-3' in different promoters. Represses transcription of E- cadherin.

Storage Conditions

ZEB2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

136447 MW

Gene Name Synonym

Zinc finger E-box binding homeobox 2

Subcellular Location

Nucleus

Protein Name

Zinc finger E-box binding homeobox 2

Isotype

IgG

Contents

ZEB2 Antibody is supplied in PBS containing 0.02% sodium azide.