Anti-P2X purinoceptor 7 P2RX7 Antibody

About this product

Boster Bio Anti-P2X purinoceptor 7 P2RX7 Antibody (Catalog # A01208) . Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse.

Specifications

Catalog number

A01208

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

The purinergic receptor P2X ligand-gated ion channel 7 (P2RX7) belongs to the family of purinoceptors for ATP (1) . This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules (1,2) . Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression (2) . Recent studies have suggested that P2RX7 may play a key role in immune-mediated diseases such as rheumatoid arthritis (3) as well as neuropsychiatric disorders (4) .

Synonyms

P2X purinoceptor 7, P2X7, purinergic receptor P2X ligand-gated ion channel 7

Gene Name

P2RX7

UniProt

Q99572

Host

Rabbit

Reactivity

Human, Mouse

Cross Reactivity

P2RX7 antibody is human, mouse, and rat reactive. Multiple isoforms of P2RX7 are known to exist.

Immunogen

P2RX7 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human P2RX7. The immunogen is located within the last 50 amino acids of P2RX7.

Clonality

Polyclonal

Tissue Specificity

Widely expressed with highest levels in brain and immune tissues.

Applications

ELISA, WB, ICC, IF

Field of Research

Signal Transduction, Immunology

Purification

P2RX7 antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells (PubMed:21821797, PubMed:23303206) .

Storage Conditions

P2RX7 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Observed Molecular Weight

68585 MW

Gene Name Synonym

Purinergic receptor P2X, ligand-gated ion channel, 7

Subcellular Location

Cell membrane

Prediction Reactivity

Rat

Protein Name

Purinergic receptor P2X, ligand-gated ion channel, 7

Isotype

IgG

Contents

P2RX7 antibody is supplied in PBS containing 0.02% sodium azide.