Anti-CD130 IL6ST Antibody

About this product

Boster Bio Anti-CD130 IL6ST Antibody catalog # A01216. Tested in WB, IHC, IF, ELISA applications. This antibody reacts with Human, Mouse.

Specifications

Catalog number

A01216

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Interleukin-6 receptor subunit beta; IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; CDw130; Interleukin-6 signal transducer; Membrane glycoprotein 130; gp130; Oncostatin-M receptor subunit alpha; CD130; IL6ST

Gene Name

IL6ST

UniProt

P40189

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

The antiserum was produced against synthesized peptide derived from human CD130/gp130. AA range:748-797

Clonality

Polyclonal

Tissue Specificity

Found in all the tissues and cell lines examined (PubMed:2261637) . Expression not restricted to IL6 responsive cells (PubMed:2261637) . Expressed in blood serum (at protein level) (PubMed:24629561) .

Applications

WB, IHC, IF, ELISA

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/mL

Form

Liquid

Function

Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:2261637) . That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003) . Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity) . Has a role in embryonic development (By similarity) . Does not bind IL6 (PubMed:2261637) . Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity) . Required for expression of TRPA1 in nociceptive neurons (By similarity) . Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity) . Required for normal trabecular bone mass and cortical bone composition (By similarity) .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

103537 MW

Gene Name Synonym

Interleukin-6 receptor subunit beta

Subcellular Location

Isoform 1: Cell membrane

Protein Name

Interleukin-6 receptor subunit beta

Isotype

IgG

Contents

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.