Anti-Lysine-specific demethylase 6A KDM6A Antibody

About this product

Boster Bio Anti-Lysine-specific demethylase 6A KDM6A Antibody catalog # A01286. Tested in WB, IHC, IF applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A01286

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Lysine-specific demethylase 6A;1.14.11.-

Gene Name

KDM6A

UniProt

O15550

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of mouse KDM6A

Clonality

Polyclonal

Applications

WB, IHC, IF

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code (PubMed:17851529, PubMed:17713478, PubMed:17761849) . Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27' (PubMed:17851529, PubMed:17713478, PubMed:17761849) . Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529) . Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (PubMed:17761849) . Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression (By similarity) .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

154177 MW

Gene Name Synonym

Lysine-specific demethylase 6A

Subcellular Location

Nucleus .

Protein Name

Lysine-specific demethylase 6A

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2