Anti-CB2 Antibody (C-term)

About this product

Boster Bio Anti-CB2 Antibody (C-term) (Catalog # A01307-3) . Tested in WB, IHC-P, Flow Cytometry application (s) . This antibody reacts with Human.

Specifications

Catalog number

A01307-3-400ul

Size / count

400 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein) -coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors.

Synonyms

Cannabinoid receptor 2, CB-2, CB2, hCB2, CX5, CNR2, CB2A, CB2B

Gene Name

CNR2

UniProt

P34972

Host

Rabbit

Reactivity

Human

Immunogen

This CB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 329-356 amino acids from the C-terminal region of human CB2.

Clonality

Polyclonal

Tissue Specificity

Preferentially expressed in cells of the immune system with higher expression in B-cells and NK cells (at protein level) . Expressed in skin in suprabasal layers and hair follicles (at protein level) . Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root ganglion sensory neurons (at protein level) . Two isoforms are produced by alternative promoter usage and differ only in the 5' UTR: isoform CB2A is observed predominantly in testis with some expression in brain, while isoform CB2B is predominant in spleen and leukocytes

Applications

WB, IHC-P, Flow Cytometry

Field of Research

Neuroscience, Inflammation

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

39681 Da

Subcellular Location

Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Perikaryon Note=Localizes to apical dendrite of pyramidal neurons.

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.