Anti-JMJD3 KDM6B Antibody

About this product

Boster Bio Anti-JMJD3 KDM6B Antibody (Catalog # A01309) . Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A01309

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

The Jumonji domain-containing protein 3 (JMJD3) functions as a trimethylation-specific demethylase, converting the trimethylated histone H3 Lys27 residue to the dimethylated form, and is thought to also function as a transcriptional repressor. JMJD3 plays a central role in regulation of posterior development, by regulating HOX gene expression. It is involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. JMJD3 can also interact with and demethylate p53, resulting in its stabilization and localization to the nucleus in mouse embryo fibroblasts during neural stem cell differentiation.

Synonyms

JMJD3, JMJD3, KIAA0346, Lysine-specific demethylase 6B, JmjC domain-containing protein 3

Gene Name

KDM6B

UniProt

O15054

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

This antibody is specific for JMJD3 and will not recognize other JMJD proteins.

Immunogen

Anti-JMJD3 antibody was raised against a peptide corresponding to 16 amino acids near the carboxy terminus of human JMJD3. The immunogen is located within amino acids 1370-1420 of JMJD3.

Clonality

Polyclonal

Applications

ELISA, WB, ICC, IF

Field of Research

Stem Cells

Purification

JMJD3 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code (PubMed:17825402, PubMed:17851529, PubMed:17713478, PubMed:18003914) . Demethylates trimethylated and dimethylated H3 'Lys-27' (PubMed:17825402, PubMed:17851529, PubMed:17713478, PubMed:18003914) . Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529) . Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation (PubMed:17825402) . Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex (By similarity) .

Storage Conditions

JMJD3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

176632 MW

Gene Name Synonym

Lysine (K) -specific demethylase 6B

Subcellular Location

Nucleus

Protein Name

Lysine (K) -specific demethylase 6B

Isotype

IgG

Contents

JMJD3 Antibody is supplied in PBS containing 0.02% sodium azide.