Anti-TIP60 KAT5 Antibody

About this product

Boster Bio Anti-TIP60 KAT5 Antibody catalog # A01393. Tested in IF, ELISA, IHC applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A01393

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Histone acetyltransferase KAT5;2.3.1.48 ;60 kDa Tat-interactive protein; Tip60; Histone acetyltransferase HTATIP; HIV-1 Tat interactive protein; Lysine acetyltransferase 5; cPLA (2) -interacting protein; KAT5; HTATIP, TIP60

Gene Name

KAT5

UniProt

Q92993

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human Tip60. AA range:56-105

Applications

IF, ELISA, IHC

Purification

Immunogen affinity purified

Concentration

1 mg/mL

Form

Liquid

Function

Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2. Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity (PubMed:17360565) . .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

58582 MW

Gene Name Synonym

Histone acetyltransferase KAT5

Subcellular Location

Nucleus . Nucleus, nucleolus. Cytoplasm, perinuclear region. Upon stimulation with EDN1, it is exported from the nucleus to the perinuclear region and UV irradiation induces translocation into punctuate subnuclear structures named nuclear bodies.

Isotype

IgG

Contents

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.