Anti-Phospho-CDC25A (T507) Antibody

About this product

Boster Bio Anti-Phospho-CDC25A (T507) Antibody (Catalog # A01433-2) . Tested in IF, WB, IHC-P application (s) . This antibody reacts with Human.

Specifications

Catalog number

A01433-2-400ul

Size / count

400 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene.

Synonyms

M-phase inducer phosphatase 1, Dual specificity phosphatase Cdc25A, CDC25A

Gene Name

CDC25A

UniProt

P30304

Host

Rabbit

Reactivity

Human

Immunogen

This CDC25A Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T507 of human CDC25A.

Clonality

Polyclonal

Applications

IF, WB, IHC-P

Field of Research

Cancer, Cell Biology

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Tyrosine protein phosphatase which functions as a dosage- dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

59087 Da

Prediction Reactivity

Bovine, Mouse, Rat

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.