- Catalog number
- A01467-1-80ul
- Size / count
- 80 µL
- Dry ice
- No
- Hazardous
- No
- Discontinued
- No
- Background
- G-protein coupled receptor for 5-hydroxytryptamine (serotonin) . Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca (2+) ions from intracellular stores. Plays a role in the regulation of 5- hydroxytryptamine release and in the regulation of dopamine and 5- hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.
- Synonyms
- 5-hydroxytryptamine receptor 1A, 5-HT-1A, 5-HT1A, G-21, Serotonin receptor 1A, HTR1A, ADRB2RL1, ADRBRL1
- Gene Name
- HTR1A
- UniProt
- P08908
- Host
- Rabbit
- Reactivity
- Human
- Immunogen
- This HTR1A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 239-273 amino acids from the Central region of human HTR1A.
- Clonality
- Polyclonal
- Tissue Specificity
- Detected in lymph nodes, thymus and spleen. Detected in activated T-cells, but not in resting T-cells
- Applications
- WB, Flow Cytometry
- Field of Research
- Cancer, Metabolism, Neuroscience, Signal Transduction
- Purification
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- Function
- G-protein coupled receptor for 5-hydroxytryptamine (serotonin) . Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca (2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.
- Storage Conditions
- Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
- Observed Molecular Weight
- 46107 Da
- Subcellular Location
- Cell membrane; Multi-pass membrane protein. Cell projection, dendrite {ECO:0000250|UniProtKB:P19327}
- Isotype
- Rabbit IgG
- Contents
- Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
