Anti-Cyclin-dependent kinase 8 Cdk8 Antibody

Catalog number A01493

Price for A01493

Size / count 100 µL

About this product

Boster Bio Anti-Cyclin-dependent kinase 8 Cdk8 Antibody catalog # A01493. Tested in WB, IHC, IF, ELISA applications. This antibody reacts with Human, Mouse.

Specifications

Catalog number: A01493
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
Synonyms: Cyclin-dependent kinase 8;2.7.11.22;2.7.11.23; Cell division protein kinase 8; Mediator complex subunit CDK8; Mediator of RNA polymerase II transcription subunit CDK8; Protein kinase K35; CDK8
Gene Name: CDK8
UniProt: P49336
Host: Rabbit
Reactivity: Human, Mouse
Immunogen: The antiserum was produced against synthesized peptide derived from human CDK8. AA range:1-50
Applications: WB, IHC, IF, ELISA
Purification: Immunogen affinity purified
Concentration: 1 mg/mL
Form: Liquid
Function: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation. .
Storage Conditions: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight: 53284 MW
Gene Name Synonym: Cyclin-dependent kinase 8
Subcellular Location: Nucleus .
Isotype: IgG
Contents: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Frequently Asked Questions

What is the catalog number for Anti-Cyclin-dependent kinase 8 Cdk8 Antibody?

The catalog number for Anti-Cyclin-dependent kinase 8 Cdk8 Antibody is A01493.

What sizes are available for Anti-Cyclin-dependent kinase 8 Cdk8 Antibody?

Anti-Cyclin-dependent kinase 8 Cdk8 Antibody is available in the following size(s): 100 µL.

Is Anti-Cyclin-dependent kinase 8 Cdk8 Antibody in stock?

Anti-Cyclin-dependent kinase 8 Cdk8 Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Where can I find the safety data sheet (SDS/MSDS) for Anti-Cyclin-dependent kinase 8 Cdk8 Antibody?

The safety data sheet for Anti-Cyclin-dependent kinase 8 Cdk8 Antibody is available here: https://www.bosterbio.com/msds?sku=A01493.

What is Anti-Cyclin-dependent kinase 8 Cdk8 Antibody used for?

Boster Bio Anti-Cyclin-dependent kinase 8 Cdk8 Antibody catalog # A01493. Tested in WB, IHC, IF, ELISA applications. This antibody reacts with Human, Mouse.

What should I check when this product first arrives?

Inspect the package immediately for transportation damage, ice loss, leakage, or breakage. Report any issues right away with photos and your order reference; our specialists will determine whether the product is still usable or needs replacing.

Does this cell line or biologic require a Material Transfer Agreement (MTA)?

Some products, including certain cell lines, plasmids, and tissue cultures, are subject to intellectual property terms and may require an MTA before we can ship. We’ll inform you in advance if this product requires one, and additional handling fees may apply.

What should I do if I need to report a performance issue with a specific lot of this product?

Provide the catalogue number, product name, lot number, and your experimental results to our technical support team. They’ll investigate and, if needed, escalate to the manufacturer, provided the product was used before expiry and stored correctly.