Anti-Alpha-2-macroglobulin A2M Antibody

About this product

Boster Bio Anti-Alpha-2-macroglobulin A2M Antibody catalog # A01498. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A01498

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Alpha-2-macroglobulin; Alpha-2-M; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; A2M; CPAMD5; FWP007

Gene Name

A2M

UniProt

P01023

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide corresponding to residues in Human A2M.

Clonality

Polyclonal

Tissue Specificity

Secreted in plasma.

Applications

WB

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced) . Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

163291 MW

Applications Notes

WB: 1:500-1:1000

Gene Name Synonym

Alpha-2-macroglobulin

Subcellular Location

Secreted

Protein Name

Alpha-2-macroglobulin

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2