Anti-Ron (phospho-S1394) MST1R Antibody

About this product

Boster Bio Anti-Ron (phospho-S1394) MST1R Antibody catalog # A01532S1394. Tested in WB applications. This antibody reacts with Human.

Specifications

Catalog number

A01532S1394

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Macrophage-stimulating protein receptor; MSP receptor;2.7.10.1; CDw136; Protein-tyrosine kinase 8; p185-Ron; CD136; Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain; MST1R; PTK8, RON

Gene Name

MST1R

UniProt

Q04912

Host

Rabbit

Reactivity

Human

Immunogen

Synthetic phosphopeptide derived from human Ron around the phosphorylation site of Serine 1394

Clonality

Polyclonal

Tissue Specificity

Expressed in colon, skin, lung and bone marrow.

Applications

WB

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

152241 MW

Applications Notes

WB: 1:500-1:1000

Gene Name Synonym

Macrophage-stimulating protein receptor

Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Name

Macrophage-stimulating protein receptor

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2