Anti-BIN1 Antibody

About this product

Boster Bio Anti-BIN1 Antibody catalog # A01551. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Rat.

Specifications

Catalog number

A01551

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Myc box-dependent-interacting protein 1; Amphiphysin II; Amphiphysin-like protein; Box-dependent myc-interacting protein 1; Bridging integrator 1; BIN1; AMPHL

Gene Name

BIN1

UniProt

O00499

Host

Rabbit

Reactivity

Human, Rat

Immunogen

Recombinant fusion protein of human BIN1 (NP_647601.1) .

Clonality

Polyclonal

Tissue Specificity

Ubiquitous. Highest expression in the brain and muscle (PubMed:9182667) . Expressed in oligodendrocytes (PubMed:27488240) . Isoform IIA is expressed only in the brain, where it is detected in the gray matter, but not in the white matter (PubMed:27488240) . Isoform BIN1 is widely expressed with highest expression in skeletal muscle.

Applications

WB, IHC, ICC, IF

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (PubMed:24755653) . Is a negative regulator of endocytosis (By similarity) . Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (PubMed:27179792) . In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (By similarity) . May be involved in the regulation of MYC activity and the control cell proliferation (PubMed:8782822) . Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro (PubMed:28893863) .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

64699 MW

Gene Name Synonym

Myc box-dependent-interacting protein 1

Subcellular Location

Isoform BIN1: Nucleus

Protein Name

Myc box-dependent-interacting protein 1

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2