Anti-BCL2L11 Antibody (Center)

About this product

Boster Bio Anti-BCL2L11 Antibody (Center) (Catalog # A01552-3) . Tested in IHC-P, Flow Cytometry, WB application (s) . This antibody reacts with Human.

Specifications

Catalog number

A01552-3-80ul

Size / count

80 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

BCL2L11 belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a Bcl-2 homology domain 3 (BH3) . It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X (L), and MCL1, and to act as an apoptotic activator.

Synonyms

Bcl-2-like protein 11, Bcl2-L-11, Bcl2-interacting mediator of cell death, BCL2L11, BIM

Gene Name

BCL2L11

UniProt

O43521

Host

Rabbit

Reactivity

Human

Immunogen

This BCL2L11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 134-160 amino acids from the Central region of human BCL2L11.

Clonality

Polyclonal

Tissue Specificity

Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are widely expressed with tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney.

Applications

IHC-P, Flow Cytometry, WB

Field of Research

Cancer, Cell Biology, Immunology, Metabolism, Neuroscience, Signal Transduction, Apoptosis, Mitochondria

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase- mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

22171 Da

Subcellular Location

Endomembrane system; Peripheral membrane protein. Note=Associated with intracytoplasmic membranes. [Isoform BimL]: Mitochondrion. [Isoform Bim-alpha1]: Mitochondrion.

Prediction Reactivity

Mouse, Rat

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.