Anti-PPARD Antibody (C-term)

About this product

Boster Bio Anti-PPARD Antibody (C-term) (Catalog # A01557) . Tested in WB application (s) . This antibody reacts with Human.

Specifications

Catalog number

A01557-80ul

Size / count

80 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants.

Synonyms

Peroxisome proliferator-activated receptor delta, PPAR-delta, NUCI, Nuclear hormone receptor 1, NUC1, Nuclear receptor subfamily 1 group C member 2, Peroxisome proliferator-activated receptor beta, PPAR-beta, PPARD, NR1C2, PPARB

Gene Name

PPARD

UniProt

Q03181

Host

Rabbit

Reactivity

Human

Immunogen

This PPARD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 364-393 amino acids from the C-terminal region of human PPARD.

Clonality

Polyclonal

Tissue Specificity

Ubiquitous with maximal levels in placenta and skeletal muscle

Applications

WB

Field of Research

Cardiovascular, Metabolism, Anti-Wnt-Pathway (plus Lgr5) Antibodies

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

35675826

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

49903 Da

Applications Notes

WB: 1:1000

Subcellular Location

Nucleus.

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.