Anti-ATR ANTXR1 Antibody

About this product

Boster Bio Anti-ATR ANTXR1 Antibody (Catalog # A01563) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A01563

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

The Anthrax toxin receptor (ATR) was initially discovered as the tumor endothelial marker 8 (TEM8) . This protein, which exists in three isoforms (36, 40, and 60 kDa), is highly expressed in tumor vessels as well as in the vasculature of developing embryos, suggesting that it may normally play a role in angiogenesis. However, it also acts as the receptor for anthrax toxin. Following the binding of this protein by the protective antigen (PA) of anthrax, PA is cleaved and heptamerizes to form the binding site for both edema factor (EF) and lethal factor (LF) . This complex is then endocytosed by the cell; acidification in endosomes allows the release of EF and LF into the cytoplasm where they interfere with MAPK signaling and induce apoptosis.

Synonyms

ATR, GAPO, TEM8, ATR, Anthrax toxin receptor 1, Tumor endothelial marker 8

Gene Name

ANTXR1

UniProt

Q9H6X2

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

At least three isoforms of ATR are known to exist; this antibody will detect all three isoforms.

Immunogen

ATR antibody was raised against a peptide corresponding to 13 amino acids near the center of human ATR. The immunogen is located within amino acids 220 - 270 of ATR.

Clonality

Polyclonal

Tissue Specificity

Detected in umbilical vein endothelial cells (at protein level) . Highly expressed in tumor endothelial cells.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Neuroscience, Infectious Diseases

Purification

ATR Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells.

Storage Conditions

ATR antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

62789 MW

Gene Name Synonym

Anthrax toxin receptor 1

Subcellular Location

Cell membrane

Protein Name

Anthrax toxin receptor 1

Isotype

IgG

Contents

ATR Antibody is supplied in PBS containing 0.02% sodium azide.