Anti-Arylsulfatase B ARSB Antibody

About this product

Boster Bio Anti-Arylsulfatase B ARSB Antibody (Catalog # A01609) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A01609

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Aryl sulfatase B (ARSB) forms a homodimer that hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate (1) . ARSB localizes to the lysozyme as well as to the extracellular matrix (2) . Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B (3), and can be treated with exogenous ARSB (4) .

Synonyms

ASB, G4S, MPS6, Arylsulfatase B, N-acetylgalactosamine-4-sulfatase, ASB

Gene Name

ARSB

UniProt

P15848

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

ARSB antibody is human, mouse and rat reactive. At least two isoforms of ARSB are known to exist; this antibody only recognizes the longest isoform.

Immunogen

ARSB antibody was raised against a 16 amino acid peptide near the carboxy terminus of human ARSB. The immunogen is located within amino acids 460 - 510 of ARSB .

Clonality

Polyclonal

Applications

ELISA, WB, IHC-P, IF

Field of Research

Homeostasis

Purification

ARSB Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (PubMed:19306108) . Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (PubMed:19306108) . In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity) .

Storage Conditions

ARSB antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Observed Molecular Weight

59687 MW

Gene Name Synonym

Arylsulfatase B

Subcellular Location

Lysosome

Protein Name

Arylsulfatase B

Isotype

IgG

Contents

ARSB Antibody is supplied in PBS containing 0.02% sodium azide.