Anti-LAT (L185) Antibody

About this product

Boster Bio Anti-LAT (L185) Antibody catalog # A01654. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A01654

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Linker for activation of T-cells family member 1;36 kDa phospho-tyrosine adapter protein; pp36; p36-38; LAT

Gene Name

LAT

UniProt

O43561

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide, corresponding to amino acids 161-210 of Human LAT.

Clonality

Polyclonal

Tissue Specificity

Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level) .

Applications

WB

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

Required for TCR (T-cell antigen receptor) - and pre-TCR- mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III) -mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor) -mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

27930 MW

Applications Notes

WB: 1:500-1:1000

Gene Name Synonym

Linker for activation of T-cells family member 1

Subcellular Location

Cell membrane

Protein Name

Linker for activation of T-cells family member 1

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2