Anti-Transcription factor SOX-17 SOX17 Antibody

About this product

Boster Bio Anti-Transcription factor SOX-17 SOX17 Antibody (Catalog # A01665) . Tested in ELISA, WB, IF applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A01665

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

SOX17 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate (1,2) . SOX17 is part of the SoxF subgroup which plays an important role in the differentiation of different cell types, including visceral and definitive endoderm and hematopoietic cell types (3,4) . SOX17 is also essential for acquisition and maintenance of arterial identity (5) .

Synonyms

VUR3, Transcription factor SOX-17

Gene Name

SOX17

UniProt

Q9H6I2

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

SOX17 antibody is human, mouse and rat reactive. SOX17 is predicted to not cross-react with other SOX proteins.

Immunogen

SOX17 antibody was raised against a 16 amino acid peptide near the center of human SOX17. The immunogen is located within amino acids 240 - 290 of SOX17.

Clonality

Polyclonal

Tissue Specificity

Expressed in adult heart, lung, spleen, testis, ovary, placenta, fetal lung, and kidney. In normal gastrointestinal tract, it is preferentially expressed in esophagus, stomach and small intestine than in colon and rectum.

Applications

ELISA, WB, IF

Field of Research

Stem Cells

Purification

SOX17 antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Acts as transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'- AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal looping of the embryonic heart tube. Required for normal development of the definitive gut endoderm. Probable transcriptional activator in the premeiotic germ cells (By similarity) . .

Storage Conditions

SOX17 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Observed Molecular Weight

44117 MW

Gene Name Synonym

RY (sex determining region Y) -box 17

Subcellular Location

Nucleus

Protein Name

RY (sex determining region Y) -box 17

Isotype

IgG

Contents

SOX17 antibody is supplied in PBS containing 0.02% sodium azide.