Anti-DDR2/Tyro10 Antibody

About this product

Boster Bio Anti-DDR2/Tyro10 Antibody catalog # A01698. Tested in IF, IHC, ELISA applications. This antibody reacts with Human, Mouse.

Specifications

Catalog number

A01698

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Discoidin domain-containing receptor 2; Discoidin domain receptor 2;2.7.10.1; CD167 antigen-like family member B; Discoidin domain-containing receptor tyrosine kinase 2; Neurotrophic tyrosine kinase, receptor-related 3; Receptor protein-tyrosine kinase TKT; Tyrosine-protein kinase TYRO10; CD167b; DDR2; NTRKR3, TKT, TYRO10

Gene Name

DDR2

UniProt

Q16832

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Synthetic peptide from human protein at AA range: 31-80

Tissue Specificity

Detected in osteocytes, osteoblastic cells in subchondral bone, bone lining cells, tibia and cartilage (at protein level) . Detected at high levels in heart and lung, and at low levels in brain, placenta, liver, skeletal muscle, pancreas, and kidney. .

Applications

IF, IHC, ELISA

Purification

Immunogen affinity purified

Concentration

1 mg/mL

Form

Liquid

Function

Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

96736 MW

Gene Name Synonym

Discoidin domain-containing receptor 2

Subcellular Location

Cell membrane ; Single- pass type I membrane protein .

Isotype

IgG

Contents

PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.