Anti-cIAP-1/HIAP-2 BIRC2 Antibody

About this product

Boster Bio Anti-cIAP-1/HIAP-2 BIRC2 Antibody (Catalog# A01700) . Tested in WB, IHC, IP application (s) . This antibody reacts with Canine, Gerbil, Human, Mouse, Rat.

Specifications

Catalog number

A01700

Size / count

50 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Baculoviral IAP repeat-containing protein 2;6.3.2.-; Cellular inhibitor of apoptosis 1; C-IAP1; IAP homolog B; Inhibitor of apoptosis protein 2; hIAP-2; hIAP2; RING finger protein 48; TNFR2-TRAF-signaling complex protein 2; BIRC2; API1, MIHB, RNF48

Gene Name

BIRC2

UniProt

Q13490

Host

Rabbit

Reactivity

Canine, Gerbil, Human, Mouse, Rat

Immunogen

Full-length recombinant protein of human cAIP1

Clonality

Polyclonal

Tissue Specificity

Present in many fetal and adult tissues. Mainly expressed in adult skeletal muscle, thymus, testis, ovary, and pancreas, low or absent in brain and peripheral blood leukocytes.

Applications

WB, IHC, IP

Field of Research

Apoptosis, Apoptotic Markers, Cancer, Cancer Metabolism, Cell Biology, Cell Death, Intracellular, Invasion/Microenvironment, Metabolism, Metabolism Processes, Pathways and Processes, Receptors, Response To Hypoxia

Concentration

0.5-1mg/mL, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Function

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin- protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin- protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs) . Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase- dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle. .

Storage Conditions

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Observed Molecular Weight

69900 MW

Gene Name Synonym

Baculoviral IAP repeat-containing protein 2

Subcellular Location

Cytoplasm. Nucleus. Agents that induce either the extrinsic or intrinsic apoptotic pathways promote its redistribution from the nuclear compartment to the cytoplasmic compartment. Associated with the midbody in telophase cells, and found diffusely in the nucleus of interphase cells.

Protein Name

Baculoviral IAP repeat-containing protein 2

Isotype

Rabbit IgG

Contents

50 μ l sera