Anti-Axin-2 AXIN2 Antibody — image 1 of 3

Product details

Anti-Axin-2 AXIN2 Antibody

Catalog number A01772

Price for A01772

Size / count 0.1 mg

About this product

Boster Bio Anti-Axin-2 AXIN2 Antibody (Catalog # A01772) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number: A01772
Size / count: 0.1 mg
Dry ice: No
Hazardous: No
Discontinued: No
Background: Like the related protein AXIN1, AXIN2 is thought to play an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway. In mouse, AXIN2 organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and AXIN2, which leads to the degradation of beta-catenin, which is thought to be an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
Synonyms: AXIL, ODCRCS, Axin-2, Axin-like protein, Axil
Gene Name: AXIN2
UniProt: Q9Y2T1
Host: Rabbit
Reactivity: Human, Mouse, Rat
Cross Reactivity: AXIN2 antibody is predicted to not cross-react with AXIN1. At least four isoforms of AXIN2 are known to exist; this antibody will recognize all four.
Immunogen: AXIN2 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of human AXIN2. The immunogen is located within amino acids 780 - 830 of AXIN2.
Clonality: Polyclonal
Tissue Specificity: Expressed in brain and lymphoblast.
Applications: ELISA, WB, IHC-P, IF
Field of Research: Cancer, Cell Cycle
Purification: AXIN2 Antibody is affinity chromatography purified via peptide column.
Concentration: 1 mg/mL
Form: Liquid
Function: Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta- catenin and APC by GSK3B (By similarity) . .
Storage Conditions: AXIN2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Observed Molecular Weight: 93558 MW
Gene Name Synonym: Axin 2
Subcellular Location: Cytoplasm.
Prediction Reactivity: Chicken
Protein Name: Axin 2
Isotype: IgG
Contents: AXIN2 Antibody is supplied in PBS containing 0.02% sodium azide.

Frequently Asked Questions

What is the catalog number for Anti-Axin-2 AXIN2 Antibody?

The catalog number for Anti-Axin-2 AXIN2 Antibody is A01772.

What sizes are available for Anti-Axin-2 AXIN2 Antibody?

Anti-Axin-2 AXIN2 Antibody is available in the following size(s): 0.1 mg.

Is Anti-Axin-2 AXIN2 Antibody in stock?

Anti-Axin-2 AXIN2 Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Where can I find the safety data sheet (SDS/MSDS) for Anti-Axin-2 AXIN2 Antibody?

The safety data sheet for Anti-Axin-2 AXIN2 Antibody is available here: https://www.bosterbio.com/msds?sku=A01772.

What is Anti-Axin-2 AXIN2 Antibody used for?

Boster Bio Anti-Axin-2 AXIN2 Antibody (Catalog # A01772) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

What is the immunogen used to generate this antibody?

Immunogen or antigen details used to raise this antibody are listed on the product datasheet under immunogen information.

What is the recommended positive control for this assay?

A recommended positive control, where one is specified by the manufacturer, is listed on the datasheet or in the assay protocol.

How should this product be stored?

Storage conditions depend on the specific reagent and are listed on the product datasheet, with most antibodies and proteins requiring -20°C unless stated otherwise. It is your responsibility to store the product correctly immediately upon receipt; damage from improper storage after delivery is not eligible for replacement.