Anti-Mouse Ring1 Antibody (C-term)

About this product

Boster Bio Anti-Mouse Ring1 Antibody (C-term) (Catalog # A01824) . Tested in WB application (s) . This antibody reacts with Mouse.

Specifications

Catalog number

A01824-400ul

Size / count

400 µL

Dry ice

No

Hazardous

No

Discontinued

No

Background

Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity (By similarity) .

Synonyms

E3 ubiquitin-protein ligase RING1, 632-, Polycomb complex protein RING1, RING finger protein 1, Transcription repressor Ring1A, Ring1, Ring1A, Rnf1

Gene Name

Ring1

UniProt

O35730

Host

Rabbit

Reactivity

Mouse

Immunogen

This Mouse Ring1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 306-340 amino acids from the C-terminal region of human Mouse Ring1.

Clonality

Polyclonal

Applications

WB

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity (By similarity) .

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

42631 Da

Applications Notes

WB: 1:1000

Subcellular Location

Nucleus speckle.

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.