Anti-OAS2 Antibody

About this product

Boster Bio Anti-OAS2 Antibody catalog # A01878. Tested in WB, IHC, IF, ELISA applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A01878

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

2'-5'-oligoadenylate synthase 2; (2-5') oligo (A) synthase 2;2-5A synthase 2;2.7.7.84

Gene Name

OAS2

UniProt

P29728

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

The antiserum was produced against synthesized peptide derived from the N-terminal region of human OAS2. AA range:61-110

Clonality

Polyclonal

Applications

WB, IHC, IF, ELISA

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/mL

Form

Liquid

Function

Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response (PubMed:10464285, PubMed:9880569) . Activated by detection of double stranded RNA (dsRNA) : polymerizes higher oligomers of 2'- 5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation (PubMed:10464285, PubMed:9880569, PubMed:11682059) . Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication (PubMed:10464285, PubMed:9880569) . Can mediate the antiviral effect via the classical RNASEL-dependent pathway or an alternative antiviral pathway independent of RNASEL (PubMed:21142819) . In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation (PubMed:21142819) . May act as a negative regulator of lactation, stopping lactation in virally infected mammary gland lobules, thereby preventing transmission of viruses to neonates (By similarity) . Non-infected lobules would not be affected, allowing efficient pup feeding during infection (By similarity) .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

82431 MW

Gene Name Synonym

2'-5'-oligoadenylate synthase 2

Subcellular Location

Cytoplasm

Protein Name

2'-5'-oligoadenylate synthase 2

Isotype

IgG

Contents

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.