Anti-NMDA Epsilon 2 (phospho-Y1336) GRIN2B Antibody

About this product

Boster Bio Anti-NMDA Epsilon 2 (phospho-Y1336) GRIN2B Antibody catalog # A01883Y1336. Tested in WB applications. This antibody reacts with Human, Rat, Mouse.

Specifications

Catalog number

A01883Y1336

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Glutamate receptor ionotropic, NMDA 2B; GluN2B; Glutamate [NMDA] receptor subunit epsilon-2; N-methyl D-aspartate receptor subtype 2B; NMDAR2B

Gene Name

GRIN2B

UniProt

Q13224

Host

Rabbit

Reactivity

Human, Rat, Mouse

Immunogen

Synthetic phosphopeptide derived from human NMDA ε 2 around the phosphorylation site of Tyrosine1336.

Clonality

Polyclonal

Tissue Specificity

Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia.

Applications

WB

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg (2+) (PubMed:8768735, PubMed:26919761, PubMed:26875626, PubMed:28126851) . Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:8768735, PubMed:26875626) . In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death. Contributes to neural pattern formation in the developing brain. Plays a role in long-term depression (LTD) of hippocampus membrane currents and in synaptic plasticity (By similarity) .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

166367 MW

Applications Notes

WB: 1:500-1:1000

Gene Name Synonym

Glutamate receptor ionotropic, NMDA 2B

Subcellular Location

Cell membrane

Protein Name

Glutamate receptor ionotropic, NMDA 2B

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2