Anti-CEP290 (F812) Antibody

About this product

Boster Bio Anti-CEP290 (F812) Antibody catalog # A01894. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A01894

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Centrosomal protein of 290 kDa; Cep290; Bardet-Biedl syndrome 14 protein; Cancer/testis antigen 87; CT87; Nephrocystin-6; Tumor antigen se2-2; CEP290; BBS14, KIAA0373, NPHP6

Gene Name

CEP290

UniProt

O15078

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide, corresponding to amino acids 781-830 of Human CEP290.

Clonality

Polyclonal

Tissue Specificity

Ubiquitous. Expressed strongly in placenta and weakly in brain.

Applications

WB

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

Involved in early and late steps in cilia formation. Its association with CCP110 is required for inhibition of primary cilia formation by CCP110 (PubMed:18694559) . May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs) . Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1 (PubMed:24421332) . Required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells; may play a role in ciliary transport processes (By similarity) . Required for efficient recruitment of RAB8A to primary cilium (PubMed:17705300) . In the ciliary transition zone is part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity) . Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2, BBS5 and BBS8/TTC8 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating IQCB1/NPHP5 (PubMed:25552655) . Activates ATF4-mediated transcription (PubMed:16682973) .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

290386 MW

Applications Notes

WB: 1:500-1:1000

Gene Name Synonym

Centrosomal protein of 290 kDa

Subcellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome

Protein Name

Centrosomal protein of 290 kDa

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2