Anti-GABARAP Antibody

About this product

Boster Bio Anti-GABARAP Antibody (Catalog # A01907) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A01907

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Gamma-aminobutyric acid (GABA) is the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing in the central nervous system. It has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. GABARAP (GABAA receptor-associated protein) links GABAA receptors to the cytoskeleton and may play a role in intracellular transport of GABAA receptors and its interaction with the cytoskeleton. GABARAP belongs to the MAP1 or ATG8 like family and recent studies show that MAPK15/ERK8 is acting through interaction with ATG8 family proteins to regulate autophagy.

Synonyms

MM46, ATG8A, GABARAP-a, FLC3B, HT004, Gamma-aminobutyric acid receptor-associated protein, MM46

Gene Name

GABARAP

UniProt

O95166

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

Multiple isoforms of GABARAP exist due to alternative splicing events.

Immunogen

GABARAP antibody was raised against a 19 amino acid peptide near the amino terminus of human GABARAP. The immunogen is located within the first 50 amino acids of GABARAP.

Clonality

Polyclonal

Tissue Specificity

Heart, brain, placenta, liver, skeletal muscle, kidney and pancreas.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Autophagy

Purification

GABARAP Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Ubiquitin-like modifier that plays a role in intracellular transport of GABA (A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.

Storage Conditions

GABARAP antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Observed Molecular Weight

13918 MW

Gene Name Synonym

GABA (A) receptor-associated protein

Subcellular Location

Endomembrane system . Cytoplasm, cytoskeleton

Prediction Reactivity

Rabbit, Bovine

Protein Name

GABA (A) receptor-associated protein

Isotype

IgG

Contents

GABARAP Antibody is supplied in PBS containing 0.02% sodium azide.