Anti-TRIM63 Antibody

About this product

Boster Bio Anti-TRIM63 Antibody catalog # A02016. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A02016

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

E3 ubiquitin-protein ligase TRIM63;2.3.2.27; Iris RING finger protein; Muscle-specific RING finger protein 1; MuRF-1; MuRF1; RING finger protein 28; RING-type E3 ubiquitin transferase TRIM63 ; Striated muscle RING zinc finger protein; Tripartite motif-containing protein 63; TRIM63; IRF, MURF1, RNF28, SMRZ

Gene Name

TRIM63

UniProt

Q969Q1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 253-353 of human TRIM63 (NP_115977.2) .

Clonality

Polyclonal

Tissue Specificity

Muscle specific. Selectively expressed in heart and skeletal muscle. Also expressed in the iris.

Applications

WB, IHC, ICC, IF

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti- hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

40248 MW

Gene Name Synonym

E3 ubiquitin-protein ligase TRIM63

Subcellular Location

Cytoplasm. Nucleus . Cytoplasm, myofibril, sarcomere, M line. Cytoplasm, myofibril, sarcomere, Z line. Colocalizes with TNNI3 in myocytes (By similarity) . Localizes to the M- and Z-lines in skeletal muscle. .

Protein Name

E3 ubiquitin-protein ligase TRIM63

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2