Anti-Acid ceramidase ASAH1 Antibody

About this product

Boster Bio Anti-Acid ceramidase ASAH1 Antibody (Catalog # A02055) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A02055

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

Sphingolipids are hydrolyzed by ceramidases to yield sphingosine and fatty acids. These ceramidases are classified according to the pH range that supports their optimal activity. ASAH1 is an acid ceramidase and key regulator of ceramide metabolism. Mutations in this gene results in Farber Lipogranulomatosis, a fatal human genetic disorder that results in the painful swelling of the joints and tendons and pulminary insufficiency, while a complete knockout of its expression is lethal in mice. Recent studies have shown elevated levels of ASAH1 in Alzheimer's disease (AD) patients correlating with a reduction in sphingomyelin and elevation of ceramide. Pretreatment of cultured neurons with recombinant AHAH1 prevented the cells from undergoing A-beta (Ab) -induced apoptosis.

Synonyms

AC, PHP, ASAH, PHP32, ACDase, SMAPME, HSD-33, HSD33, Acid ceramidase, Acylsphingosine deacylase, AC

Gene Name

ASAH1

UniProt

Q13510

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

Multiple isoforms of ASAH1 are known to exist.

Immunogen

ASAH1 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of the human ASAH1. The immunogen is located within amino acids 240 - 290 of ASAH1.

Clonality

Polyclonal

Tissue Specificity

Broadly expressed with highest expression in heart.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Homeostasis

Purification

ASAH1 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.

Storage Conditions

ASAH1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

44660 MW

Gene Name Synonym

N-acylsphingosine amidohydrolase (acid ceramidase) 1

Subcellular Location

Lysosome.

Prediction Reactivity

Bovine

Protein Name

N-acylsphingosine amidohydrolase (acid ceramidase) 1

Isotype

IgG

Contents

ASAH1 Antibody is supplied in PBS containing 0.02% sodium azide.