Product details

Anti-HIF1AN Antibody

Catalog number A02116

Price for A02116

Size / count 100 µL

About this product

Boster Bio Anti-HIF1AN Antibody catalog # A02116. Tested in WB, ICC/IF, IP applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number: A02116
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
Synonyms: Hypoxia-inducible factor 1-alpha inhibitor;1.14.11.30;1.14.11.n4; Factor inhibiting HIF-1; FIH-1; Hypoxia-inducible factor asparagine hydroxylase; HIF1AN; FIH1
Gene Name: HIF1AN
UniProt: Q9NWT6
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant fusion protein of human HIF1AN/FIH1 (NP_060372.2) .
Clonality: Polyclonal
Applications: WB, ICC, IF, IP
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration: 1 mg/mL
Form: Liquid
Function: Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD) . Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300- interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.
Storage Conditions: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight: 40285 MW
Gene Name Synonym: Hypoxia-inducible factor 1-alpha inhibitor
Subcellular Location: Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mainly cytoplasmic localization, but interaction with NOTCH1 results in nuclear localization and interaction with ABPA3 results in perinuclear localization in macrophages.
Protein Name: Hypoxia-inducible factor 1-alpha inhibitor
Contents: Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Frequently Asked Questions

What is the catalog number for Anti-HIF1AN Antibody?

The catalog number for Anti-HIF1AN Antibody is A02116.

What sizes are available for Anti-HIF1AN Antibody?

Anti-HIF1AN Antibody is available in the following size(s): 100 µL.

Is Anti-HIF1AN Antibody in stock?

Anti-HIF1AN Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Where can I find the safety data sheet (SDS/MSDS) for Anti-HIF1AN Antibody?

The safety data sheet for Anti-HIF1AN Antibody is available here: https://www.bosterbio.com/msds?sku=A02116.

What is Anti-HIF1AN Antibody used for?

Boster Bio Anti-HIF1AN Antibody catalog # A02116. Tested in WB, ICC/IF, IP applications. This antibody reacts with Human, Mouse, Rat.

Can I get a trial-size or discounted first order of this product?

We don’t generally offer free samples, but trial discounts in exchange for feedback and validation results are almost always possible. Contact us with your intended application to arrange one.

Do you offer bulk or custom quantities of this product?

Yes. Ordering two or more units, or combining this with other products, usually qualifies for a discount depending on quantity. Contact our sales team with your required volume for a custom quote.

Do you provide a Certificate of Analysis (CoA) for this product?

A Certificate of Analysis is available for most products upon request. Contact our support team with the lot number to obtain the relevant CoA.