Anti-TRPV6 Antibody

About this product

Boster Bio Anti-TRPV6 Antibody catalog # A02139. Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A02139

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Transient receptor potential cation channel subfamily V member 6; TrpV6; CaT-like

Gene Name

TRPV6

UniProt

Q9H1D0

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide of human TRPV6 (NP_061116.5) .

Clonality

Polyclonal

Tissue Specificity

Expressed at high levels in the gastrointestinal tract, including esophagus, stomach, duodenum, jejunum, ileum and colon, and in pancreas, placenta, prostate and salivary gland. Expressed at moderate levels in liver, kidney and testis. Expressed in trophoblasts of placenta villus trees (at protein level) (PubMed:23612980) . Expressed in locally advanced prostate cancer, metastatic and androgen-insensitive prostatic lesions but not detected in healthy prostate tissue and benign prostatic hyperplasia.

Applications

WB, IHC

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Concentration

1 mg/mL

Form

Liquid

Function

Calcium selective cation channel that mediates Ca (2+) uptake in various tissues, including the intestine (PubMed:11097838, PubMed:11278579, PubMed:11248124 PubMed:15184369, PubMed:23612980, PubMed:29258289) . Important for normal Ca (2+) ion homeostasis in the body, including bone and skin (By similarity) . The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification (PubMed:15184369) . Inactivation includes both a rapid Ca (2+) - dependent and a slower Ca (2+) -calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg (2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5- TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

87286 MW

Gene Name Synonym

Transient receptor potential cation channel subfamily V member 6

Subcellular Location

Cell membrane

Protein Name

Transient receptor potential cation channel subfamily V member 6

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2