Anti-Syntenin SDCBP Antibody

About this product

Boster Bio Anti-Syntenin SDCBP Antibody catalog # A02475. Tested in WB, ICC, IF, IHC, Flow Cytometry, IP applications. This antibody reacts with Human.

Specifications

Catalog number

A02475

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Syntenin-1; Melanoma differentiation-associated protein 9; MDA-9; Pro-TGF-alpha cytoplasmic domain-interacting protein 18; TACIP18; Scaffold protein Pbp1; Syndecan-binding protein 1; SDCBP; MDA9, SYCL

Gene Name

SDCBP

UniProt

O00560

Host

Rabbit

Reactivity

Human

Immunogen

Recombinant protein within human Syntenin aa 1-200.

Clonality

Polyclonal

Tissue Specificity

Expressed in lung cancers, including adenocarcinoma, squamous cell carcinoma and small-cell carcinoma (at protein level) (PubMed:25893292) . Widely expressed. Expressed in fetal kidney, liver, lung and brain. In adult highest expression in heart and placenta.

Applications

WB, ICC, IF, IHC, Flow Cytometry, IP

Purification

ProA affinity purified

Concentration

1 mg/mL

Form

Liquid

Function

Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527) . Positively regulates TGFB1- mediated SMAD2/3 activation and TGFB1-induced epithelial-to- mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292) . In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413) . Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120) . In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591) . May also play a role in vesicular trafficking (PubMed:11179419) . Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395) .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

32444 MW

Gene Name Synonym

Syntenin-1

Subcellular Location

Cell junction, focal adhesion

Protein Name

Syntenin-1

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2