Anti-Stk39 Antibody

About this product

Boster Bio Anti-Stk39 Antibody (Catalog # A02516) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.

Specifications

Catalog number

A02516

Size / count

0.1 mg

Dry ice

No

Hazardous

No

Discontinued

No

Background

The serine/threonine kinase Stk39 belongs to the STE20 family, a group of kinases that are known to interact with inflammation-related kinases (such as p38, JNK, NKCC1, PKC-theta, WNK and MLCK), and with transcription factor AP-1. The STE 20 family is involved in diverse biological phenomena, including cell differentiation, cell transformation/ proliferation, cytoskeleton rearrangement, and the regulation of ion transporters. STK39 contains an N-terminal series of proline and alanine repeats (PAPA box), followed by a serine/threonine kinase catalytic domain and is abundantly expressed in the brain. STK39 is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled co-transporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. Recent studies show that STK39 tend to be a novel candidate gene for autism and hypertension.

Synonyms

DCHT, PASK, SPAK, DCHT, Ste-20-related kinase

Gene Name

STK39

UniProt

Q9UEW8

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Stk39 antibody was raised against a 19 amino acid synthetic peptide from near the carboxy terminus of human Stk39. The immunogen is located within amino acids 450 - 500 of Stk39.

Clonality

Polyclonal

Tissue Specificity

Predominantly expressed in brain and pancreas followed by heart, lung, kidney, skeletal muscle, liver, placenta and testis.

Applications

ELISA, WB, IHC-P, IF

Field of Research

Signal Transduction

Purification

Stk39 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Form

Liquid

Function

May act as a mediator of stress-activated signals. Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation. Phosphorylates RELT.

Storage Conditions

Stk39 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed Molecular Weight

59474 MW

Gene Name Synonym

Serine threonine kinase 39 (STE20/SPS1 homolog, yeast)

Subcellular Location

Cytoplasm . Nucleus . Nucleus when caspase-cleaved. .

Prediction Reactivity

Rat, Pig

Protein Name

Serine threonine kinase 39 (STE20/SPS1 homolog, yeast)

Isotype

IgG

Contents

Stk39 Antibody is supplied in PBS containing 0.02% sodium azide.