Anti-USP9x Antibody

About this product

Boster Bio Anti-USP9x Antibody catalog # A02594. Tested in WB, ICC, IF, IHC, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

A02594

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Probable ubiquitin carboxyl-terminal hydrolase FAF-X;3.4.19.12; Deubiquitinating enzyme FAF-X; Fat facets in mammals; hFAM; Fat facets protein-related, X-linked; Ubiquitin thioesterase FAF-X; Ubiquitin-specific protease 9, X chromosome; Ubiquitin-specific-processing protease FAF-X; USP9X

Gene Name

USP9X

UniProt

Q93008

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within human USP9X aa 1-200.

Clonality

Polyclonal

Tissue Specificity

Widely expressed in embryonic and adult tissues.

Applications

WB, ICC, IF, IHC, Flow Cytometry

Purification

ProA affinity purified

Concentration

1 mg/mL

Form

Liquid

Function

Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Specifically hydrolyzes 'Lys-48'-, 'Lys- 29'- and 'Lys-33'-linked polyubiquitins chains. Essential component of TGF-beta/BMP signaling cascade. Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Deubiquitinates alkylation repair enzyme ALKBH3. OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111) . Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres. Involved in axonal growth and neuronal cell migration (PubMed:16322459, PubMed:18254724, PubMed:19135894, PubMed:24607389) . Regulates cellular clock function by enhancing the protein stability and transcriptional activity of the core circadian protein ARNTL/BMAL1 via its deubiquitinating activity (PubMed:29626158) .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

292280 MW

Gene Name Synonym

Probable ubiquitin carboxyl-terminal hydrolase FAF-X

Subcellular Location

Cytoplasm

Protein Name

Probable ubiquitin carboxyl-terminal hydrolase FAF-X

Contents

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2